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They are convenient
models of small nodular tumors in the avascular stage
of growth and provide a three-dimensional cellular
environment that is appropriate for studying intercellular and intracellular signaling.
Although there is a paucity of data evaluating the outcomes of preoperative
chemoradiation for upper rectal cancers the authors suggest that T3N0 tumors will not likely benefit from radiation
and that treatment of T4N0 should be individualized.
In this context, we are interested in the
design, the synthesis and the study of smart biomolecular structures capable of redirecting
endogenous antibodies present in the human bloodstream against tumors.
(http://thejns.org/doi/abs/10.3171/2014.5.SPINE13992)
Key Words • stem cells • olfactory ensheathing cells • spinal cord injury •
tumor • olfactory mucosa • human • cell transplantation • oncology
H
uman neural stem cells and cell transplantation
are being investigated as potential therapies for
neurodegenerative diseases, congenital disorders,
stroke, spinal cord injury (SCI), traumatic brain injury,
and brain tumors.7–9,13,14 However, concerns have been
raised over the safety of this experimental therapeutic approach.8 Most concerning is whether de novo tumors can
develop from transplanted stem cells or supporting cells.
TRAIL, récepteur de mort DR5, apoptose, cancer, thérapie ciblée, peptides cycliques, ponts disulfure,
ligands, multivalence, structure, approche combinatoire, criblage sur billes de résine, fluorescence, sondes
Synthesis and use of multimeric peptide architectures to gain insight into the
mechanism of activation of the death receptor DR5
A major challenge in clinical cancer research is to develop more selective approaches that can
specifically target tumors while minimizing undesirable toxic effects.
Presentation 2016
2
NanoXray positioned to become a standard of care
in oncology
First in class radioenhancer that could change everything without
changing anything
1
Lead product has shown to be both safe and efficacious in “ultimate tumor case”
Derisking the all concept
Allows for higher dose/efficacy without increasing toxicity
2
Versatile application to target the majority of the oncology market
Broad pipeline in six major indications with potential expansion in most of solid tumors
NanoXray can easily be combined with chemotherapy, immuno-oncology …
3
Disruptive innovation compatible with care in current hospital setting
Disruptive innovation in existing and well structured radiotherapy market
Does not require change of the existing infrastructure, protocol, training
4
Several key milestones in the coming 12 months
Sarcoma Phase II/III interim data mid 2016 and CE mark end of 2016
Data in Liver cancer Phase I/II starting H2 2016
Results of Phase I/II H&N cancer H1 2016
Presentation 2016
3
Nanobiotix applies physics to cancer treatment
Molecules
(drugs and biologics)
Nanotechnology
supports the effect of
molecules
Nano-object becomes
the active principle
1940’s
1980’s
2000
Today
Chemistry
Biology
Nanosized drug
delivery system
New therapeutic
tools based on
physics
50nm
e.g.
For instance, if a T1-weighted scan is performed (the
measure of T1 is used to differentiate tissues), low-T1 environments like fat, melanin and slowly
flowing blood will appear white whereas high-T1 environments like water, edemas, tumors,
inflammation, bone and air will appear black.
17.03.2011
A variety of etiological factors including disorders of
the hypothalamo-pituitary axis, interruption of dopamine
synthesis, stress, pituitary tumors, polycystic ovary
syndrome, primary hypothyroidism, and various medications
may lead to hyperprolactinemia (1).